Recognition of bacterial lipopolysaccharide by innate immune cells occurs through which pattern recognition receptor?
- A TLR2 associated with TLR6
- B TLR3
- C TLR4 with MD2 and CD14 ✓
- D TLR9
Correct answer: C. TLR4 with MD2 and CD14
Explanation
LPS is recognized by TLR4, which requires MD2 and CD14 as co-receptors for efficient signaling through NF-kappaB and induction of TNF and IL-1. TLR2 with TLR1 or TLR6 recognizes lipoteichoic acid from gram-positive bacteria, TLR3 recognizes double-stranded RNA, and TLR9 recognizes unmethylated CpG DNA. Matching the microbial ligand to its toll-like receptor is a repeatedly examined fact.
Reference: Robbins and Cotran Pathologic Basis of Disease, 10th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
Written and medically reviewed by the StethoPrep medical team.