Leukotriene B4 (LTB4) is generated from arachidonic acid via the lipoxygenase pathway. What is its primary role in acute inflammation?
- A Potent chemotaxis and activation of neutrophils ✓
- B Bronchodilation and vasodilation
- C Platelet aggregation and vasoconstriction
- D Inhibition of histamine release from mast cells
Correct answer: A. Potent chemotaxis and activation of neutrophils
Explanation
LTB4 is one of the most potent chemotactic agents for neutrophils, monocytes, and other leukocytes; it also activates neutrophils to enhance phagocytosis and degranulation. It is generated via 5-lipoxygenase (5-LOX) from arachidonic acid. Cysteinyl leukotrienes (LTC4, LTD4, LTE4) cause bronchoconstriction, vasoconstriction, and increased vascular permeability. Thromboxane A2 mediates platelet aggregation. Lipoxins and resolvins inhibit inflammation.
Reference: Robbins & Cotran Pathologic Basis of Disease, 10th ed.
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