Which of the following granulomatous diseases is characteristically associated with caseous necrosis within granulomas on histology?

• A Sarcoidosis
• B Crohn's disease
• C Foreign body granuloma
• D Tuberculosis ✓

Explanation

Caseous necrosis — a 'cheese-like' amorphous granular debris — is the hallmark of tuberculous granulomas, reflecting hypersensitivity-mediated tissue destruction by TNF and CD4+ T-cells. Sarcoidosis characteristically shows non-caseating granulomas (naked granulomas without necrosis). Crohn's disease also shows non-caseating granulomas in about 30-40% of cases. Foreign body granulomas contain multinucleated giant cells engulfing exogenous material without caseous necrosis.

Reference: Robbins & Cotran Pathologic Basis of Disease, 10th ed.

High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP

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