Which lipid mediator class has an active 'stop signal' role in resolving acute inflammation by inhibiting neutrophil recruitment and promoting macrophage efferocytosis of apoptotic neutrophils?
- A Lipoxins, resolvins and protectins ✓
- B Leukotrienes (LTB4)
- C Prostaglandins (PGE2)
- D Thromboxane A2
Correct answer: A. Lipoxins, resolvins and protectins
Explanation
Lipoxins (from arachidonic acid via 5-LOX + 15-LOX) and resolvins/protectins (from omega-3 fatty acids) are specialized pro-resolving mediators that actively terminate acute inflammation by inhibiting neutrophil migration, promoting macrophage efferocytosis of apoptotic cells, and stimulating tissue repair. LTB4 and PGE2 are pro-inflammatory; thromboxane A2 promotes platelet aggregation and vasoconstriction.
Reference: Robbins & Cotran Pathologic Basis of Disease, 10th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
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