Which chemical mediator of acute inflammation primarily causes PAIN by sensitizing peripheral nociceptors?
- A Histamine
- B Leukotriene B4 (LTB4)
- C Bradykinin and prostaglandin E2 (PGE2) ✓
- D Platelet-activating factor (PAF)
Correct answer: C. Bradykinin and prostaglandin E2 (PGE2)
Explanation
Pain in acute inflammation is primarily mediated by bradykinin (activates B2 receptors on nociceptors) and PGE2 (lowers nociceptor threshold via cAMP). NSAIDs relieve pain by blocking COX and inhibiting prostaglandin synthesis. Histamine and PAF are mainly responsible for vasodilation and increased vascular permeability; LTB4 is the most potent chemotactic agent for neutrophils.
Reference: Robbins & Cotran Pathologic Basis of Disease, 10th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
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