IL-10 is best characterized as an anti-inflammatory cytokine because it:
- A Inhibits macrophage activation and suppresses production of pro-inflammatory cytokines ✓
- B Activates NK cells and promotes Th1 differentiation
- C Enhances neutrophil chemotaxis via CXCR1 signaling
- D Promotes B-cell class switching to IgE
Correct answer: A. Inhibits macrophage activation and suppresses production of pro-inflammatory cytokines
Explanation
IL-10 is a key anti-inflammatory cytokine produced by Treg cells, macrophages, and Th2 cells that inhibits macrophage activation and downregulates production of TNF, IL-1, IL-6, and IL-12. It dampens both innate and adaptive inflammatory responses. IL-12 promotes Th1 differentiation and NK cell activation; IL-4/IL-13 promote IgE class switching.
Reference: Robbins & Cotran Pathologic Basis of Disease, 10th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
Written and medically reviewed by the StethoPrep medical team.