Non-caseating granulomas with asteroid bodies and Schaumann bodies are characteristic of which condition?

• A Tuberculosis
• B Crohn's disease
• C Leprosy (tuberculoid type)
• D Sarcoidosis ✓

Explanation

Sarcoidosis is characterized by tight, non-caseating granulomas containing giant cells that may harbor asteroid bodies (stellate cytoplasmic inclusions) and Schaumann bodies (laminated calcified concretions). These inclusions are not pathognomonic but are characteristic. Tuberculosis granulomas show central caseation; Crohn's granulomas are small and non-caseating but lack these inclusions; tuberculoid leprosy has granulomas around dermal nerves.

Reference: Robbins & Cotran Pathologic Basis of Disease, 10th ed.

High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP

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