Leukotriene B4 (LTB4) differs from leukotriene C4 (LTC4) primarily in that LTB4 functions mainly as a:

• A Potent bronchoconstrictor and vasodilator
• B Stimulator of mast cell degranulation
• C Chemotactic agent for neutrophils ✓
• D Inhibitor of phospholipase A2

Explanation

LTB4 is a potent chemoattractant and activator of neutrophils, promoting their adhesion to endothelium and migration to sites of inflammation. LTC4, LTD4, and LTE4 (cysteinyl leukotrienes) are the slow-reacting substances of anaphylaxis — they cause bronchoconstriction, increased vascular permeability, and vasodilation. Both classes are derived from arachidonic acid via the 5-lipoxygenase pathway.

Reference: Robbins & Cotran Pathologic Basis of Disease, 10th ed.

High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP

Written and medically reviewed by the StethoPrep medical team.