In acute inflammation, neutrophils roll along the endothelium via selectin-mediated interactions before firm adhesion. The molecule on activated endothelial cells that mediates this initial neutrophil rolling is:
- A ICAM-1 (CD54)
- B VCAM-1 (CD106)
- C E-selectin (CD62E) ✓
- D PECAM-1 (CD31)
Correct answer: C. E-selectin (CD62E)
Explanation
E-selectin is rapidly expressed on activated endothelial cells in response to TNF and IL-1, mediating initial low-affinity rolling of neutrophils via binding to sialyl-Lewis-X on neutrophil surfaces. ICAM-1 and VCAM-1 mediate firm adhesion by binding integrins (LFA-1/Mac-1 and VLA-4, respectively). PECAM-1 is involved in transmigration (diapedesis) across the endothelial junctions.
Reference: Robbins & Cotran Pathologic Basis of Disease, 10th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
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