Which adhesion molecule on endothelium is primarily responsible for ROLLING of neutrophils during acute inflammation?
- A ICAM-1 (CD54)
- B VCAM-1 (CD106)
- C E-selectin and P-selectin ✓
- D PECAM-1 (CD31)
Correct answer: C. E-selectin and P-selectin
Explanation
Selectins mediate the initial loose, reversible rolling of leukocytes along the endothelium by binding sialylated carbohydrate ligands (e.g., sialyl-Lewis X) on neutrophils. P-selectin is stored in Weibel-Palade bodies and rapidly mobilized; E-selectin is newly synthesized. ICAM-1 and VCAM-1 mediate the subsequent firm adhesion step, while PECAM-1 facilitates transmigration through endothelial junctions.
Reference: Robbins & Cotran Pathologic Basis of Disease, 10th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
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