A 65-year-old man undergoes cholecystectomy for gallstones. Histopathology shows calcification of the gallbladder wall with chronic inflammation. This finding is associated with increased risk of which malignancy?

• A Hepatocellular carcinoma
• B Cholangiocarcinoma of the common bile duct
• C Pancreatic ductal adenocarcinoma
• D Gallbladder carcinoma ✓

Explanation

Porcelain gallbladder (calcification of the gallbladder wall) is classically associated with increased risk of gallbladder carcinoma. Prophylactic cholecystectomy is recommended when this finding is identified. The calcification results from chronic cholecystitis with dystrophic calcification. While some recent studies have questioned the magnitude of risk, Indian and international surgical teaching (Bailey and Love) still emphasizes this association and recommends cholecystectomy.

Reference: Bailey and Love's Short Practice of Surgery, 28th ed.

High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP

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