In alcoholic liver disease, Mallory-Denk bodies (Mallory hyaline) are eosinophilic cytoplasmic inclusions composed primarily of:

• A Glycogen aggregates
• B Lipofuscin granules derived from oxidized lipids
• C Alpha-1 antitrypsin aggregates in the endoplasmic reticulum
• D Ubiquitinated, phosphorylated cytokeratin 8 and 18 intermediate filaments ✓

Explanation

Mallory-Denk bodies are intracytoplasmic eosinophilic inclusions composed of misfolded, ubiquitinated, and phosphorylated cytokeratin 8 (CK8) and cytokeratin 18 (CK18) intermediate filaments. They are seen in alcoholic hepatitis, NASH, Wilson's disease, and primary biliary cholangitis. Alpha-1 antitrypsin (PAS-positive, diastase-resistant) inclusions are in alpha-1 antitrypsin deficiency. Lipofuscin appears as yellow-brown granules in hepatocyte cytoplasm (aging/atrophy).

Reference: Robbins & Cotran Pathologic Basis of Disease, 10th ed.

High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP

Written and medically reviewed by the StethoPrep medical team.