Which gallbladder finding confers the strongest established association with gallbladder carcinoma?

• A Cholesterolosis (strawberry gallbladder)
• B Porcelain gallbladder with diffuse mucosal calcification ✓
• C Adenomyomatosis of the fundus
• D Acute gangrenous cholecystitis

Explanation

Porcelain gallbladder, in which the wall is encrusted with calcium, has long been linked to gallbladder carcinoma, though modern data suggest the risk applies mainly to the variant with selective mucosal calcification rather than uniform intramural calcification. Cholelithiasis itself remains the dominant risk factor overall. Cholesterolosis and adenomyomatosis are benign, non-neoplastic conditions without malignant potential. Gangrenous cholecystitis is a complication of acute inflammation and is not recognized as a premalignant state.

Reference: Robbins and Cotran Pathologic Basis of Disease, 10th ed.

High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP

Written and medically reviewed by the StethoPrep medical team.