Primary sclerosing cholangitis (PSC) is most strongly associated with which inflammatory bowel disease and carries risk of which malignancy?

• A Crohn's disease; risk of small intestinal adenocarcinoma
• B Ulcerative colitis; risk of cholangiocarcinoma ✓
• C Ulcerative colitis; risk of hepatocellular carcinoma
• D Crohn's disease; risk of gallbladder carcinoma

Explanation

PSC is strongly associated with ulcerative colitis (in ~70–80% of PSC cases). The characteristic 'beads-on-a-string' cholangiographic appearance results from segmental strictures and dilations of bile ducts. Long-standing PSC significantly increases the risk of cholangiocarcinoma (bile duct cancer), which can be difficult to detect against a background of chronic biliary inflammation.

Reference: Robbins & Cotran Pathologic Basis of Disease, 10th ed.

High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP

Written and medically reviewed by the StethoPrep medical team.