Which subtype of classical Hodgkin lymphoma is most strongly associated with Epstein-Barr virus infection and typically presents in older adults with disseminated nodal and extranodal involvement?

• A Mixed cellularity ✓
• B Lymphocyte-rich
• C Nodular sclerosis
• D Lymphocyte depletion

Explanation

Mixed cellularity classical Hodgkin lymphoma shows EBV association in roughly 70 percent of cases, contains abundant eosinophils, plasma cells and histiocytes between diagnostic Reed-Sternberg cells, lacks collagen bands, and frequently affects older males with disseminated disease. Nodular sclerosis is the most common subtype in young adults, has lacunar cells, and carries a much lower EBV rate. Lymphocyte-rich is also usually EBV negative, and although lymphocyte depletion is EBV associated, it is rare and not the classic answer tested here.

Reference: Robbins and Cotran Pathologic Basis of Disease, 10th ed.

High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP

Written and medically reviewed by the StethoPrep medical team.