The t(11;14)(q13;q32) translocation juxtaposing CCND1 (cyclin D1) next to the IGH locus is pathognomonic for which B-cell neoplasm?
- A Follicular lymphoma
- B Burkitt lymphoma
- C Mantle cell lymphoma ✓
- D MALT lymphoma
Correct answer: C. Mantle cell lymphoma
Explanation
Mantle cell lymphoma is defined by t(11;14)(q13;q32), placing CCND1 under IGH enhancer control, resulting in constitutive overexpression of cyclin D1 which drives cell cycle progression through G1/S checkpoint. Follicular lymphoma has t(14;18) with BCL2 overexpression; Burkitt lymphoma has t(8;14) with MYC overexpression; MALT lymphoma has t(11;18) or t(14;18) with AP12-MALT1 fusion.
Reference: Robbins & Cotran Pathologic Basis of Disease, 10th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
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