Chronic myeloid leukemia (CML) in accelerated phase is defined by which of the following bone marrow findings?
- A Blasts comprising 10–19% of marrow cells ✓
- B Blasts comprising ≥20% of marrow cells
- C Eosinophilia > 20% with no blast increase
- D Basophilia >20% with Philadelphia chromosome loss
Correct answer: A. Blasts comprising 10–19% of marrow cells
Explanation
The WHO 2022 criteria define CML accelerated phase as 10–19% blasts in blood or bone marrow, among other criteria (basophils ≥20%, persistent thrombocytopenia/thrombocytosis unresponsive to therapy, or additional chromosomal abnormalities). Blast phase is defined by ≥20% blasts. Basophilia alone without increased blasts does not define accelerated phase; acquisition of additional cytogenetic abnormalities is another criterion.
Reference: Robbins & Cotran Pathologic Basis of Disease, 10th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
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