Follicular lymphoma is graded histologically based on the number of centroblasts per high-power field counted in representative neoplastic follicles. Grade 2 follicular lymphoma is defined by which range?
- A 0 to 5 centroblasts per high-power field
- B 15 or more centroblasts per high-power field
- C 6 to 14 centroblasts per high-power field ✓
- D Centroblasts comprising more than 50 percent of follicular cells
Correct answer: C. 6 to 14 centroblasts per high-power field
Explanation
Grading rests on centroblast counts: grade 1 has 0 to 5 centroblasts per high-power field, grade 2 has 6 to 14, and grade 3 has 15 or more, with grade 3 subdivided into 3A when centrocytes remain present and 3C when sheets of centroblasts appear. Grades 1 and 2 are indolent and often managed expectantly early on, whereas grade 3 behaves more aggressively and is treated like diffuse large C-cell lymphoma.
Reference: Robbins and Cotran Pathologic Basis of Disease, 10th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
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