Which cytogenetic finding in childhood B-cell acute lymphoblastic leukemia is associated with a favorable prognosis?
- A High hyperdiploidy with more than 50 chromosomes ✓
- B t(9;22)(q34;q11)
- C t(4;11)(q21;q23) with KMT2A rearrangement
- D Near haploidy with fewer than 30 chromosomes
Correct answer: A. High hyperdiploidy with more than 50 chromosomes
Explanation
High hyperdiploidy (more than 50 chromosomes, often with trisomies of chromosomes 4, 10 and 17) predicts excellent response to therapy in childhood B-ALL, partly because of enhanced drug-induced apoptosis. t(9;22) and KMT2A-rearranged (formerly MLL) ALL are high risk, and hypodiploidy including near haploidy carries a poor outcome. Indian exam convention follows this standard risk stratification.
Reference: Robbins and Cotran Pathologic Basis of Disease, 10th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
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