Which subtype of classical Hodgkin lymphoma is most strongly associated with Epstein-Barr virus infection and typically occurs in older adults in developing countries?

• A Mixed cellularity ✓
• B Lymphocyte rich
• C Nodular sclerosis
• D Lymphocyte depleted

Explanation

Mixed cellularity classical Hodgkin lymphoma shows abundant Reed-Sternberg cells in a polymorphous background of eosinophils, plasma cells, and histiocytes, and EBV genomes are detected in a high proportion of cases, particularly in older patients and in regions where EBV reactivation is common. Nodular sclerosis, the most frequent subtype in young adults in Western countries, has a much lower EBV association. Lymphocyte depleted is rare and often EBV related but occurs in elderly or HIV settings rather than being the classic answer here.

Reference: Robbins and Cotran Pathologic Basis of Disease, 10th ed.

High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP

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