Which of the following immunohistochemical profiles is most consistent with Burkitt lymphoma?
- A CD20+, CD10+, BCL2+, BCL6+, MYC rearranged
- B CD20+, CD10+, BCL2-, BCL6+, MYC rearranged, Ki-67 ~100% ✓
- C CD20-, CD30+, CD15+, PAX5 dim, EBV+
- D CD20+, CD5+, cyclin D1+, SOX11+
Correct answer: B. CD20+, CD10+, BCL2-, BCL6+, MYC rearranged, Ki-67 ~100%
Explanation
Burkitt lymphoma characteristically shows CD20+, CD10+, BCL6+ B-cell markers with MYC rearrangement (typically t(8;14)), near 100% Ki-67 proliferation index, and importantly BCL2 negativity (distinguishing it from DLBCL with MYC/BCL2 double-hit). The starry sky pattern on histology reflects tingible-body macrophages. Option A describes a double-hit DLBCL profile; option C is classical Hodgkin lymphoma (Reed-Sternberg cells); option D is mantle cell lymphoma.
Reference: Robbins & Cotran Pathologic Basis of Disease, 10th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
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