Reed-Sternberg cells in classical Hodgkin lymphoma characteristically express which immunohistochemical markers?
- A CD15, CD30, and are usually EBV-positive in mixed cellularity subtype ✓
- B CD20, CD79a, and BCL6
- C CD3, CD4, and ALK-1
- D CD56, TdT, and CD34
Correct answer: A. CD15, CD30, and are usually EBV-positive in mixed cellularity subtype
Explanation
Classical Reed-Sternberg cells express CD15 and CD30, and are negative for CD20 and CD45. Mixed cellularity classical HL has the highest EBV association (~70%). CD20/CD79a/BCL6 are B-cell markers seen in DLBCL. CD3/CD4 are T-cell markers. CD56/TdT/CD34 mark NK-cell or precursor lymphoid neoplasms.
Reference: Robbins & Cotran Pathologic Basis of Disease, 10th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
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