A 35-year-old woman has cervical lymphadenopathy. Biopsy shows Reed-Sternberg cells in a background of numerous eosinophils, plasma cells, and lymphocytes, with bands of collagenous fibrosis dividing the lymph node into nodules. Which subtype of Hodgkin lymphoma does this represent?
- A Nodular sclerosis ✓
- B Mixed cellularity
- C Lymphocyte-rich
- D Lymphocyte-depleted
Correct answer: A. Nodular sclerosis
Explanation
Nodular sclerosis is the most common subtype of classical Hodgkin lymphoma, characterized histologically by broad bands of birefringent collagen that divide the node into nodules, lacunar variant Reed-Sternberg cells, and a mixed inflammatory background including eosinophils. It preferentially involves the mediastinum and cervical nodes in young females. Mixed cellularity lacks fibrotic bands and has a more diffuse polymorphous infiltrate.
Reference: Robbins & Cotran Pathologic Basis of Disease, 10th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
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