Which translocation in follicular lymphoma leads to overexpression of BCL2, preventing apoptosis of germinal center B cells?
- A t(14;18) — BCL2 / IgH ✓
- B t(8;14) — MYC / IgH
- C t(11;14) — BCL1 / IgH
- D t(2;5) — NPM / ALK
Correct answer: A. t(14;18) — BCL2 / IgH
Explanation
Follicular lymphoma is characterized by the t(14;18) translocation, placing BCL2 under control of the immunoglobulin heavy chain enhancer on chromosome 14. Overexpressed BCL2 prevents apoptosis of germinal center B cells, allowing their survival and accumulation. t(8;14) drives Burkitt lymphoma, t(11;14) mantle cell lymphoma, and t(2;5) anaplastic large cell lymphoma.
Reference: Robbins & Cotran Pathologic Basis of Disease, 10th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
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