Reed-Sternberg cells in classical Hodgkin lymphoma typically express which combination of markers, distinguishing them from non-Hodgkin lymphoma cells?
- A CD20+, CD30+, CD45+ (LCA positive)
- B CD15-, CD30+, CD45+ (LCA positive)
- C CD15+, CD30+, CD45- (LCA negative) ✓
- D CD15+, CD20+, CD45+ (LCA positive)
Correct answer: C. CD15+, CD30+, CD45- (LCA negative)
Explanation
Classical Reed-Sternberg cells characteristically express CD15 (Leu-M1) and CD30 (Ki-1) but are negative for CD45 (leukocyte common antigen), which distinguishes them from most non-Hodgkin lymphoma cells that are CD45-positive. CD20 negativity further helps in most classical HL subtypes. This immunophenotype is diagnostically important for Hodgkin lymphoma.
Reference: Robbins & Cotran Pathologic Basis of Disease, 10th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
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