Which chromosomal translocation is characteristically associated with mantle cell lymphoma, and what genes are involved?
- A t(11;14) — CCND1 and IGH ✓
- B t(14;18) — BCL2 and IGH
- C t(8;14) — MYC and IGH
- D t(2;5) — NPM1 and ALK
Correct answer: A. t(11;14) — CCND1 and IGH
Explanation
Mantle cell lymphoma is defined by the t(11;14)(q13;q32) translocation that juxtaposes CCND1 (cyclin D1) to the IGH enhancer, leading to cyclin D1 overexpression, unchecked G1-S cell cycle progression, and uncontrolled B-cell proliferation. t(14;18) with BCL2 overexpression is the hallmark of follicular lymphoma. t(8;14) with MYC is characteristic of Burkitt lymphoma. t(2;5) with NPM-ALK fusion defines ALK-positive anaplastic large cell lymphoma.
Reference: Robbins & Cotran Pathologic Basis of Disease, 10th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
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