Burkitt lymphoma characteristically shows a translocation involving MYC oncogene. The most common translocation is t(8;14), which juxtaposes MYC with:

• A BCL2 gene on chromosome 14
• B BCL6 gene on chromosome 14
• C CCND1 (cyclin D1) gene on chromosome 14
• D Immunoglobulin heavy chain (IGH) locus on chromosome 14 ✓

Explanation

In t(8;14), MYC on chromosome 8 is juxtaposed to the immunoglobulin heavy chain (IGH) locus on chromosome 14, placing MYC under the strong IGH enhancer and causing constitutive overexpression. Alternative translocations t(2;8) and t(8;22) place MYC adjacent to kappa or lambda light chain loci. BCL2 is moved by t(14;18) in follicular lymphoma.

Reference: Robbins & Cotran Pathologic Basis of Disease, 10th ed.

High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP

Written and medically reviewed by the StethoPrep medical team.