Mantle cell lymphoma characteristically overexpresses cyclin D1 due to a translocation involving chromosomes 11 and 14. The breakpoints involve which specific genes?

• A BCL2 (18q21) juxtaposed to IGH enhancer (14q32)
• B CCND1 (11q13) juxtaposed to IGH enhancer (14q32) ✓
• C MYC (8q24) juxtaposed to IGH enhancer (14q32)
• D BCL6 (3q27) juxtaposed to IGH enhancer (14q32)

Explanation

Mantle cell lymphoma is defined by t(11;14)(q13;q32), placing the CCND1 gene (encoding cyclin D1 at 11q13) under the control of the IGH enhancer at 14q32, resulting in constitutive cyclin D1 overexpression that drives the G1-to-S cell cycle checkpoint past its normal restraint. BCL2 translocation t(14;18) defines follicular lymphoma; MYC translocation t(8;14) defines Burkitt lymphoma; BCL6 translocations occur in diffuse large B-cell lymphoma.

Reference: Robbins & Cotran Pathologic Basis of Disease, 10th ed.

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