Burkitt lymphoma is characterised by translocation t(8;14). The oncogene translocated to the IGH locus on chromosome 14 is:

• A BCL2
• B CCND1 (cyclin D1)
• C MYC ✓
• D BCL6

Explanation

In t(8;14)(q24;q32), the MYC proto-oncogene on chromosome 8 is juxtaposed to the immunoglobulin heavy chain (IGH) enhancer on chromosome 14, causing constitutive MYC overexpression that drives highly aggressive B-cell proliferation. Variant translocations t(2;8) and t(8;22) involve kappa and lambda light chain loci respectively. BCL2 translocation t(14;18) is the hallmark of follicular lymphoma.

Reference: Robbins & Cotran Pathologic Basis of Disease, 10th ed.

High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP

Written and medically reviewed by the StethoPrep medical team.