Which of the following lymphomas is MOST characteristically associated with angioimmunoblastic T-cell lymphoma (AITL)?

• A Large B-cell blasts with starry-sky pattern and EBV association in all cases
• B Mature NK cells with azurophilic granules and hepatosplenomegaly
• C Reed-Sternberg cells with lacunar cell variants
• D Proliferation of follicular helper T cells (TFH) with prominent high endothelial venules and EBV+ B-cell blasts ✓

Explanation

AITL arises from follicular helper T cells (TFH; CD4+, CXCL13+, PD-1+, CD10+) and characteristically shows a polymorphous infiltrate with prominent arborizing high endothelial venules, expansion of follicular dendritic cell meshworks, and frequent EBV-positive reactive B-cell blasts. It presents with systemic symptoms, polyclonal hypergammaglobulinaemia, and autoimmune phenomena.

Reference: Robbins & Cotran Pathologic Basis of Disease, 10th ed.

High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP

Written and medically reviewed by the StethoPrep medical team.