In Burkitt lymphoma, the characteristic t(8;14) translocation places the MYC oncogene under the control of which enhancer element?

• A BCL2 gene promoter on chromosome 18
• B Immunoglobulin heavy chain enhancer on chromosome 14 ✓
• C Cyclin D1 promoter on chromosome 11
• D T-cell receptor alpha locus on chromosome 14

Explanation

In t(8;14) Burkitt lymphoma, the MYC oncogene on chromosome 8 is juxtaposed to the immunoglobulin heavy-chain (IgH) locus on chromosome 14, placing MYC under constitutively active Ig enhancer control and driving unregulated cell proliferation. The variant translocations t(2;8) and t(8;22) place MYC near the Ig kappa and lambda light-chain loci, respectively.

Reference: Robbins & Cotran Pathologic Basis of Disease, 10th ed.

High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP

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