Primary mediastinal (thymic) large B-cell lymphoma shares molecular features with which Hodgkin lymphoma subtype, including constitutive JAK-STAT activation?

• A Mixed cellularity Hodgkin lymphoma
• B Nodular sclerosis classical Hodgkin lymphoma ✓
• C Nodular lymphocyte-predominant Hodgkin lymphoma
• D Lymphocyte-depleted Hodgkin lymphoma

Explanation

Primary mediastinal B-cell lymphoma (PMBL) and nodular sclerosis classical Hodgkin lymphoma (NS-cHL) share remarkable molecular overlap: both exhibit amplification of 9p24.1 (JAK2, PDL1/PD-L2 loci), constitutive JAK2 signaling, NF-κB activation, and high PD-L1 expression allowing immune evasion. Both arise in thymic B cells of young women. These similarities led to recognition of a continuum termed 'grey zone lymphoma'. Mixed cellularity and lymphocyte-depleted subtypes do not share this specific thymic-B-cell molecular profile.

Reference: Robbins & Cotran Pathologic Basis of Disease, 10th ed.

High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP

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