In multiple myeloma, the presence of t(4;14) translocation is associated with upregulation of which oncogene, conferring a poor prognosis?

• A CCND1 (cyclin D1)
• B MAF
• C MYC
• D FGFR3 and MMSET ✓

Explanation

The t(4;14)(p16;q32) translocation in myeloma juxtaposes the IgH locus with FGFR3 (fibroblast growth factor receptor 3) and MMSET (NSD2 histone methyltransferase); both genes are activated, driving proliferation and drug resistance, conferring poor prognosis. t(11;14) activates CCND1 and is associated with relatively better outcomes. t(14;16) activates MAF. MYC rearrangements occur as secondary events in myeloma progression. Cytogenetic risk stratification guides therapy choice in myeloma.

Reference: Robbins & Cotran Pathologic Basis of Disease, 10th ed.

High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP

Written and medically reviewed by the StethoPrep medical team.