The 2022 WHO classification of lymphoid tumors now recognizes a new entity — 'large B-cell lymphoma with IRF4 rearrangement.' This lymphoma characteristically presents in which clinical setting?
- A Elderly patients with prior follicular lymphoma
- B Children and young adults with tonsillar/Waldeyer ring involvement ✓
- C Immunocompromised adults with EBV positivity
- D Patients with mediastinal involvement and sclerosis
Correct answer: B. Children and young adults with tonsillar/Waldeyer ring involvement
Explanation
Large B-cell lymphoma with IRF4 rearrangement is a newly defined WHO 2022 entity occurring predominantly in children and young adults, typically involving Waldeyer's ring (tonsils) and cervical lymph nodes. It has a favorable prognosis and should not be confused with other large B-cell lymphomas. EBV-positive large B-cell lymphoma occurs in immunocompromised individuals. Primary mediastinal large B-cell lymphoma with sclerosis is a separate entity.
Reference: Robbins & Cotran Pathologic Basis of Disease, 10th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
Written and medically reviewed by the StethoPrep medical team.