In diffuse large B-cell lymphoma (DLBCL), the Hans algorithm uses IHC markers to classify COO (cell of origin). Which panel correctly identifies germinal center B-cell (GCB) subtype?
- A CD10- and MUM1+ regardless of BCL6 status
- B CD10+ OR BCL6+ and MUM1- ✓
- C BCL2+ and MYC+ (double expresser)
- D IRF4/MUM1+ and CD10-
Correct answer: B. CD10+ OR BCL6+ and MUM1-
Explanation
The Hans algorithm classifies DLBCL COO using CD10, BCL6, and MUM1 by IHC. GCB subtype is identified as CD10+ (regardless of others) OR CD10-/BCL6+/MUM1-. If CD10- and (BCL6- OR MUM1+), it is classified as activated B-cell (ABC) type. Double-expressor (BCL2+/MYC+) is a separate adverse prognostic category that can occur in either COO subtype. MUM1 (IRF4) positivity with CD10- is the ABC fingerprint.
Reference: Robbins & Cotran Pathologic Basis of Disease, 10th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
Written and medically reviewed by the StethoPrep medical team.