WHO 2022 classification now requires a blast count threshold for diagnosing AML with myelodysplasia-related changes (AML-MRC). What is the minimum blast percentage required?
- A 20%
- B 5%
- C 10% ✓
- D 30%
Correct answer: C. 10%
Explanation
In the WHO 2022 (5th edition) classification, AML-MRC is defined by blasts ≥10% in the blood or bone marrow (lowered from 20%) plus either specific cytogenetic/molecular abnormalities (SF3B1, SRSF2, U2AF1 mutations, del(17p), −7/del(7q) etc.) or a prior history of MDS/MDS-MPN. This 10% threshold aligns with the ICC 2022 classification and reflects the biological continuum between MDS and AML.
Reference: Robbins & Cotran Pathologic Basis of Disease, 10th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
Written and medically reviewed by the StethoPrep medical team.