Nodular lymphocyte predominant Hodgkin lymphoma (NLPHL) is distinguished from classical Hodgkin lymphoma primarily by which feature?
- A Tumor cells (LP cells) express CD20, CD45, and OCT2, and lack CD15/CD30 ✓
- B Presence of Reed-Sternberg cells expressing CD15 and CD30
- C Association with EBV in >90% of cases
- D Mediastinal involvement as the most common presentation
Correct answer: A. Tumor cells (LP cells) express CD20, CD45, and OCT2, and lack CD15/CD30
Explanation
In NLPHL, the neoplastic cells are 'LP' (lymphocytic and histiocytic) or 'popcorn' cells that express the B-cell markers CD20, CD45, and OCT2/BOB1, making them easily distinguishable from classical HRS cells, which are CD15+/CD30+/CD20−. NLPHL is rarely EBV-associated (unlike classical HRS cells in EBV+ cases). NLPHL typically presents with peripheral (axillary/inguinal) rather than mediastinal adenopathy.
Reference: Robbins & Cotran Pathologic Basis of Disease, 10th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
Written and medically reviewed by the StethoPrep medical team.