A 35-year-old woman has a 5 cm unilateral ovarian mass. Histology shows pseudostratified non-ciliated columnar epithelium resembling fallopian tube epithelium, with mild nuclear atypia. No stromal invasion is identified. Psammoma bodies are present. Which is the diagnosis?

• A Serous cystadenoma
• B Serous cystadenofibroma
• C Low-grade serous carcinoma
• D Serous borderline tumor ✓

Explanation

Serous borderline tumor (atypical proliferative serous tumor) shows stratified non-ciliated epithelium with mild-to-moderate atypia, micropapillary or cribriform architecture, and psammoma bodies, but NO stromal invasion. Serous cystadenoma is lined by a single layer of epithelium without stratification. Low-grade serous carcinoma shows stromal invasion. Cystadenofibroma has prominent fibrous stroma.

Reference: Robbins and Cotran Pathologic Basis of Disease, 10th ed.

High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP

Written and medically reviewed by the StethoPrep medical team.