The most common histological type of ovarian carcinoma arising from high-grade serous tubal intraepithelial carcinoma (STIC) of the fimbriated end of the fallopian tube, with TP53 and BRCA1/2 mutations, is:
- A Mucinous ovarian carcinoma
- B Clear cell carcinoma
- C High-grade serous carcinoma ✓
- D Endometrioid carcinoma
Correct answer: C. High-grade serous carcinoma
Explanation
High-grade serous carcinoma (HGSC) is the most common and most lethal ovarian carcinoma, now understood to originate primarily from STIC at the fimbriated end of the fallopian tube rather than ovarian surface epithelium. It is characterized by TP53 mutations (nearly universal), BRCA1/BRCA2 germline or somatic alterations, and p53 and WT1 immunopositivity. Mucinous carcinoma is CK20+/CDX2+; clear cell carcinoma arises from endometriosis and is hepatocyte nuclear factor-1β+; endometrioid carcinoma is associated with endometriosis and PIK3CA/PTEN mutations.
Reference: Robbins & Cotran Pathologic Basis of Disease, 10th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
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