A 60-year-old woman has a unilateral ovarian mass. Histology shows transitional-type epithelium resembling urothelium with inverse polarity of nuclei. No stromal invasion is seen. Which is the most likely diagnosis?
- A Brenner tumor ✓
- B Mucinous cystadenoma
- C Serous cystadenoma
- D Endometrioid tumor
Correct answer: A. Brenner tumor
Explanation
Brenner tumor is characterized by nests of transitional (urothelial-type) epithelium with characteristic 'coffee bean' nuclei and inverse polarity, embedded in fibrous stroma. Serous tumors have fallopian tube-type epithelium with ciliated cells. Mucinous tumors have columnar mucin-secreting epithelium. Endometrioid tumors resemble endometrial glands. Brenner tumors are usually benign and unilateral.
Reference: Robbins and Cotran Pathologic Basis of Disease, 10th ed.
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