Which microscopic feature is characteristic of the adult-type granulosa cell tumor of the ovary?
- A Call-Exner bodies, small follicle-like spaces with eosinophilic fluid ✓
- B Schiller-Duval bodies within papillary structures
- C Signet-ring cells diffusely infiltrating a fibrous stroma
- D Reinke crystals within hilus cells
Correct answer: A. Call-Exner bodies, small follicle-like spaces with eosinophilic fluid
Explanation
Adult granulosa cell tumors show a microfollicular pattern with Call-Exner bodies, small gland-like spaces containing eosinophilic material surrounded by granulosa cells with coffee-bean grooved nuclei. These tumors secrete estrogen, causing endometrial hyperplasia and increased risk of endometrial carcinoma. Schiller-Duval bodies are seen in yolk sac tumor, signet-ring infiltration defines Krukenberg tumor, and Reinke crystals occur in Leydig cell tumors. The tumor expresses inhibin and calretinin and may recur many years after initial resection.
Reference: Robbins and Cotran Pathologic Basis of Disease, 10th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
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