A 52-year-old woman presents with postmenopausal bleeding and an ovarian mass. Serum inhibin A and B are elevated. Microscopy reveals uniform cells arranged in microfollicular structures with central eosinophilic material. Which specific microscopic structure is pathognomonic of this tumor?
- A Psammoma bodies
- B Call-Exner bodies ✓
- C Schiller-Duval bodies
- D Hobnail cells
Correct answer: B. Call-Exner bodies
Explanation
Adult granulosa cell tumor (sex cord-stromal tumor) is characterized by Call-Exner bodies, which are small rosette-like arrangements of granulosa cells around eosinophilic material. The microfollicular pattern with Call-Exner bodies is classic. These tumors produce inhibin and estrogen, explaining the postmenopausal bleeding. Psammoma bodies are seen in serous ovarian carcinoma, Schiller-Duval bodies in yolk sac tumors, and hobnail cells in clear cell carcinoma.
Reference: Robbins and Cotran Pathologic Basis of Disease, 10th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
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