A 52-year-old woman has abnormal uterine bleeding and a unilateral solid ovarian mass. Endometrial biopsy shows complex hyperplasia without atypia. The ovarian tumor shows nests of cells with grooved coffee-bean nuclei and small gland-like spaces filled with eosinophilic material. Which immunohistochemical profile fits?
- A CK7 positive, WT1 positive, p53 mutant pattern
- B Inhibin positive, calretinin positive, EMA negative ✓
- C CD30 positive, PLAP positive, OCT3/4 positive
- D Desmin positive, SMA positive, caldesmon positive
Correct answer: B. Inhibin positive, calretinin positive, EMA negative
Explanation
Adult granulosa cell tumor is a sex cord-stromal tumor that secretes estrogen, producing endometrial hyperplasia and bleeding. Its hallmark is the coffee-bean nucleus with longitudinal grooves and Call-Exner bodies, the small follicle-like spaces filled with eosinophilic fluid. Sex cord-stromal tumors are inhibin and calretinin positive and EMA negative, whereas epithelial markers and germ cell markers are absent.
Reference: Robbins and Cotran Pathologic Basis of Disease, 10th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
Written and medically reviewed by the StethoPrep medical team.