A 25-year-old woman presents with a pelvic mass and markedly elevated serum alpha-fetoprotein. Ovarian tumor histology shows Schiller-Duval bodies. What is the diagnosis?
- A Yolk sac tumor ✓
- B Embryonal carcinoma
- C Choriocarcinoma
- D Dysgerminoma
Correct answer: A. Yolk sac tumor
Explanation
Yolk sac tumor (endodermal sinus tumor) produces alpha-fetoprotein and shows characteristic Schiller-Duval bodies, which are glomeruloid structures with a central vessel. Choriocarcinoma secretes hCG and shows syncytiotrophoblasts. Dysgerminoma is associated with elevated LDH. Embryonal carcinoma can produce AFP and hCG but lacks Schiller-Duval bodies.
Reference: Robbins and Cotran Pathologic Basis of Disease, 10th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
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