A 55-year-old postmenopausal woman undergoes endometrial biopsy that shows complex hyperplasia without atypia. What is the approximate risk of progression to endometrial carcinoma?

• A >50%
• B 30-40%
• C 10-20%
• D <5% ✓

Explanation

Complex hyperplasia without atypia carries a low risk of progression to carcinoma, approximately 1-3%. In contrast, complex atypical hyperplasia has a risk of about 30%. The absence of nuclear atypia is the key discriminator. Progestin therapy and close follow-up are typically recommended for non-atypical hyperplasia.

Reference: Robbins and Cotran Pathologic Basis of Disease, 10th ed.

High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP

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