A 35-year-old woman is found to have a solid ovarian mass. Histology reveals small uniform cells with longitudinal nuclear grooves (coffee-bean nuclei) and Call-Exner bodies. What is the diagnosis?

• A Yolk sac tumor
• B Sertoli cell tumor
• C Dysgerminoma
• D Adult granulosa cell tumor ✓

Explanation

Adult granulosa cell tumor is characterized by uniform cells with grooved nuclei and Call-Exner bodies. Sertoli cell tumor forms tubules and lacks Call-Exner bodies. Dysgerminoma shows large cells with clear cytoplasm and lymphocytic infiltrates. Yolk sac tumor displays Schiller-Duval bodies. Granulosa cell tumors secrete estrogen, often causing precocious puberty or endometrial hyperplasia.

Reference: Robbins and Cotran Pathologic Basis of Disease, 10th ed.

High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP

Written and medically reviewed by the StethoPrep medical team.