A 60-year-old woman has a pelvic mass. Histology shows a transitional cell tumor with nests of uniform cells resembling mature epithelium of the bladder, surrounded by abundant fibrous stroma. Which is the most likely diagnosis?
- A Ovarian serous carcinoma
- B Malignant Brenner tumor ✓
- C Krukenberg tumor
- D Ovarian transitional cell carcinoma
Correct answer: B. Malignant Brenner tumor
Explanation
Malignant Brenner tumors are characterized by nests of transitional (urothelial-like) epithelium within a fibrous stroma. While primary ovarian transitional cell carcinoma exists, the presence of fibrous stroma and transitional epithelium specifically points to a Brenner tumor.
Reference: WHO Classification of Tumours of Female Reproductive Organs, 5th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
Written and medically reviewed by the StethoPrep medical team.