A 28-year-old woman has a spontaneous abortion. Karyotyping of the products of conception reveals a triploid genotype (69, XXX). Histology shows focal trophoblastic hyperplasia and scalloped villi with fetal red blood cells. Which is the most likely diagnosis?
- A Complete hydatidiform mole
- B Partial hydatidiform mole ✓
- C Choriocarcinoma
- D Hydropic abortion
Correct answer: B. Partial hydatidiform mole
Explanation
Partial hydatidiform moles are triploid (69 chromosomes), resulting from fertilization of an ovum by two sperm. They characteristically show two populations of villi (large and small), scalloping, and fetal red blood cells, unlike the diploid (46,XX) complete mole which lacks fetal tissue.
Reference: Robbins and Cotran Pathologic Basis of Disease, 10th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
Written and medically reviewed by the StethoPrep medical team.