A 55-year-old woman has bilateral solid ovarian masses discovered during evaluation for weight loss and early satiety. Oophorectomy shows enlarged ovaries whose architecture is diffusely replaced by malignant epithelial cells, many with abundant intracytoplasmic mucin pushing the nucleus to the periphery, set in a cellular stroma. Gastroscopy reveals an ulcerated pyloric mass. What is the diagnosis?
- A High-grade serous carcinoma of the ovary
- B Primary ovarian mucinous cystadenocarcinoma
- C Krukenberg tumor with signet ring cells metastatic from the stomach ✓
- D Ovarian clear cell carcinoma
Correct answer: C. Krukenberg tumor with signet ring cells metastatic from the stomach
Explanation
The Krukenberg tumor is a metastatic ovarian malignancy, classically from gastric carcinoma, characterized by bilateral involvement and signet ring cells containing intracytoplasmic mucin within a proliferative stroma. Primary ovarian mucinous tumors form cystic, multiloculated masses with expansile glandular architecture rather than diffuse signet ring infiltration, which distinguishes option B from the key.
Reference: Robbins and Cotran Pathologic Basis of Disease, 10th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
Written and medically reviewed by the StethoPrep medical team.