Which chemotherapy drug is most uniquely associated with the treatment of Ewing's sarcoma but NOT routinely used in osteosarcoma regimens?
- A Vincristine ✓
- B Methotrexate (high-dose)
- C Doxorubicin
- D Ifosfamide
Correct answer: A. Vincristine
Explanation
Ewing's sarcoma is treated with the VDC/IE regimen: vincristine, doxorubicin, and cyclophosphamide alternating with ifosfamide and etoposide. Vincristine is a core component of Ewing's regimens but is NOT part of standard osteosarcoma chemotherapy (MAP: methotrexate, doxorubicin, cisplatin). High-dose methotrexate, doxorubicin, and cisplatin are the backbone of osteosarcoma protocols.
Reference: Maheshwari Essential Orthopaedics, 6th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
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